【摘要】探讨正常妊娠妇女妊娠各期血清碱性磷酸酶(ALP)值的变化规律并分析其参考值范围。方法：采用日本Au640型全自动生化分析仪检测400例早、中、晚期妊娠妇女(实验组)及56名未孕健康育龄妇女的血清ALP值(对照组)。结果：对照组血清ALP值为(67.2±19.8)U/L，早期妊娠时ALP为(47.2±15.1)U/L，比对照组明显降低(P<0.01);中期妊娠时ALP值为(68.7±21.2)U/L，与对照组比较差异无显著性(P>0.05);晚期妊娠时ALP值为(156.8±52.3)U/L，比对照组比较显著升高(P<0.01)。血清ALP值随孕周的增加而上升。结论：正常妊娠时，孕妇体内ALP值在早孕时降低，中孕时无明显变化，晚孕时快速升高，建议建立晚孕期ALP参考值范围，以利于孕期保健。
【关键词】 妊娠;碱性磷酸酶;参考值范围
Measurement of the serum alkaline phosphatase level in normal pregnant women and analysis of the normal level range in different gestationperiod
HUANG Lifang, ZHU Chunhua
(The First Hospital of Shaoguan，Guangdong 512000， China; The North Hospital of Hunan Technological University, Xiangtan, Hunan 411201， China)
【Abstract】 Objective: To observe the serum alkaline phosphatase (ALP) level in normal pregnant women and analyze the normal level range in different gestationperiod. Methods: The serum level of ALP from 400 pregnant women in early, middle and late gestational period and 56 normal nonpregnant women as the control were measured with an Au640 automatic biochemical analyzer according to the IFCCrecommended method. Results: The serum ALP level was (67.2±19.8) U/L in the control, (47.2±15.1) U/L in the early gestational stage (lower than in the control, P<0.01), (68.7±21.2) U/L in the middle gestational stage (no significant difference from that in the control, P>0.05),and (156.8±52.3)U/L in the later gestational period (remarkably higher than in the control, P<0.01). Conclusion: The serum ALP level may decrease during the early gestational stage, recover to the normal level during the middle gestational stage, and increase during the later gestational period, with which a set of the normal serum ALP level range can be set up to aid to monitor the health pregnancy.
【Key words】 gestation; alkaline phosphatase; pregnancy
碱性磷酸酶(ALP)广泛存在于人体各组织中，临床上血清碱性磷酸酶测定主要用于肝脏和骨骼疾病的诊断，但妊娠妇女也会出现碱性磷酸酶的生理性增高。为探讨妊娠各期ALP活
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