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妊高征患者血浆中末端补体复合物的测定及其意义 |
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上官毕文 黄醒华 张春红 张俊芝
【摘要】 目的 探讨末端补体复合物(SC5b-9)在妊高征发病中的作用及其与血管内皮细胞损伤的关系。方法 采用酶联免疫吸附试验(ELISA)检测47例妊高征患者(妊高征组)、15例有妊高征高危因素者（高危组）和40例正常孕妇(对照组)血浆中SC5b-9含量，同时测定循环免疫复合物(CIC)、纤维结合蛋白(Fn)含量。结果 (1)妊高征组及高危组SC5b-9含量增高、CIC含量下降，与对照组比较，差异有极显著性(P<0.01)。中、重度妊高征患者Fn含量增高，与对照组比较，差异有极显著性(P<0.01)。(2)妊高征组及高危组 SC5b-9的异常(<450 μg/L)率明显高于对照组(P<0.01),中、重度妊高征组Fn的异常（<308 g/L)率明显高于对照组(P<0.01)。结论 循环免疫复合物是补体激活的起始物质，补体活化的末端产物参与了妊高征的发生和发展，并与血管内皮细胞损伤有着密切关系。
【关键词】 妊娠并发征，心血管 高血压 补体膜攻击复合物 纤连蛋白类
A Study of Plasma Terminal SC5b-9 Complement Complex in Patients with Pregnancy Induced Hypertension
SHANGGUAN Biwen, HUANG Xinghua, ZHANG Chunhong, et al.
Obstetrics and Gynecology Hospital of Beijing, Beijing 100006
【Abstract】 Objective To study the relationship between complement SC5b-9 complex and damage of vascular endothelial in pregnancy induced hypertension(PIH) . Methods Plasma SC5b-9, Serum circulate immunocomplex (CIC), fibronectin (Fn) levels were determined with ELISA in 47 cases of PIH (study group 1) and 15 cases with potential risk factors of PIH (study group 2) and 40 cases of normal pregnancies (control group). Results SC5b-9 level increased and CIC level decreased significantly in study group 1 and study group 2 than that in control group (P<0.01). The Fn level increased in moderate and severe PIH cases than that of mild PIH and control group (P<0.01). The positive rates of SC5b-9 in study group 1 and study group 2 were significantly higher than those of the control group (P<0.01).The positive rate of Fn in moderate and severe PIH cases significantly higher than those of mild PIH cases and control group (P<0.01). Conclusion Complement was activated by classical pathway. Terminal SC5b-9 complement complex play an important roles in the pathogenesis of PIH and has close relationship with vascular endthelial damage.
【Key words】 Pregnancy complications, cardiovascular Hypertensi[1] [2] 下一页
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