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卵巢上皮性癌脑转移四例临床分析 |
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赵彦 钱和年 李蔚范 戴玲
【摘要】 目的 探讨卵巢上皮性癌脑转移的发生率、相关因素、诊断和治疗方法。方法 分析1989年至1997年,卵巢上皮性癌132例,其中4例发生脑转移。结果 脑转移发生率为3%,脑转移发生与晚期癌和肿瘤分化程度有关,与肿瘤病理类型无关。晚期患者接受肿瘤细胞减灭术和系统化疗后生存时间延长;出现腹腔外转移者,脑转移发生率增高。结论 颅脑计算机体层摄影术和磁共振显像检查是确诊脑转移的重要手段。综合治疗包括手术、放疗、化疗和降颅压,可改善脑转移症状。 【关键词】 卵巢肿瘤 脑肿瘤 综合疗法
Cerebral Metastases in Patients with Epithelial Ovarian Carcinoma
ZHAO Yan, QIAN Henian, LI Weifan, et al.
Gynecologic Oncology Center, People s Hospital, Beijing Medical University, Beijing 100044
【Abstract】 Objective To detect the rate of occurrence, the relevant factors ,the diagnosis and treatment of cerebral metastases in patients with epithelial ovarian carcinoma. Methods The clinical data were analyzed in 4 cases of cerebral metastases from 132 cases of epithelial ovarian carcinoma after treatment between 1989~1997. Results The rate of cerebral metastases was 3%. The related factors were advanced stage, and tumor cells differentiation, but no related with the histologic type. More cases of cerebral metastasis were found because of the prolonged survival after cytoreductive surgery and systemic chemotherapy as well as the extraabdominal metastasis. Conclusions Computed tomography and magnetic resonance imaging were the important diagnostic methods. Combined treatments including surgery, radiotherapy and chemotherapy can improve the patients status and prolong their lives. 【Key words】 Ovarian neoplasms Brain neoplasms Combined modality therapy
卵巢上皮性癌(卵巢癌)发生脑转移的病例过去极为少见。随着肿瘤细胞减灭术的提高,和以铂类为主的联合化疗药物的应用,卵巢癌患者的生存期得以延长。近年来,陆续有卵巢癌发生脑转移[1-7]的报道。本研究复习了1989年至1997年间,在本院接收治疗的卵巢癌132例,其中发生脑转移4例。现将这4例患者的情况并复习有关文献总结分析如下。
临床资料 例1 患者49岁,因双侧卵巢混合性乳头状腺癌,于1989年5月30日接受子宫、双侧附件、大网膜切除和左侧髂外淋巴结活检。术后残留癌直径>2cm。临床病理分期为Ⅲb期,G3。术后采用顺铂、阿霉素、环磷酰胺(PAC)方案化疗6个疗程。二次探查术阴性。又巩固治疗4个疗程。此后,门诊随访和信访。第1次手术后临床无病变期26个月,至1991年8月,因头痛、眩晕、剧烈呕吐、不能行走和语言障碍2个月就诊,脑计算机体层摄影术(CT)检查提示右侧小脑占位性病变。于第1次术后28个月行开颅手术,切除右侧小脑肿物4cm×4cm×3cm。病理[1] [2] 下一页 上一个医学论文: nm23 下一个医学论文: 卵巢癌抗独特型抗体6B11scFv和人粒细胞
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