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郭彩霞 魏丽惠 富琪 周蓉 虞有智 虞幸
【摘要】 目的 研究nm23-H1基因在子宫内膜癌中的表达， 探讨其与子宫内膜癌临床各参数之间的相关性，了解nm23-H1基因对子宫内膜癌预后的影响。方法 采用免疫组化染色链霉素亲合素-生物素标记法（LSAB）检测子宫内膜癌60例。 结果 nm23-H1基因在60例子宫内膜癌中的阳性表达率为55.0%。nm23-H1基因在早期子宫内膜癌中的阳性表达率为65.9%，明显高于晚期的25.0%（P<0.01）；在高、中、低分化癌中的阳性率分别为66.7%、63.6%、 29.4%（P<0.05）；10例有淋巴结转移的子宫内膜癌中 2例表达阳性，37例无淋巴结转移的子宫内膜癌中24例表达阳性，阳性率分别为20.0%和64.9%（P<0.05）；nm23-H1基因表达阳性者生存率明显高于阴性者，5年生存率分别为90.5%和55.3%（P<0.05）。结论 nm23-H1基因抑制子宫内膜癌发展及淋巴结转移，并与预后有关。
【关键词】 子宫内膜肿瘤 淋巴转移 预后 基因，抑制，肿瘤
The Expression of nm23-H1 Genes with Clinical Prognosis in Endometrial Carcinoma
GUO Caixia, WEI Lihui, FU Qi, et al.
The Frist Hospital Baotou Medical College，Baotou 014010
【Abstract】 Objective To study the expression of nm23-H1 gene in endometrial carcinoma and its relationships between the clinicopathological parameter and prognosis of endometrial carcinoma. Methods The endometril specimens of 60 cases with endometrial carcinoma were studied retrospectively by immunohistochemical stainings. Results The positive expression rate of nm23-H1gene in endometrial carcinoma was 55.0%(33/60). The positive rate of nm23-H1 in early endometrial carcinoma was significantly higher than that in advanced cases (65.9% and 25.0%, respectively, P<0.05). Positive rates in the well and moderately differentiated endometrial carcinoma were also higher than those of poorly differentiated (66.7%, 63.6%, 29.4%, P<0.05). 20.0% of the cases with and 64.9% of the cases without lymph node metastasis showed positive for nm23-H1 (P<0.05). The expression of nm23-H1 was not correlated with histological type、myometrial invasion、 estrogen receptor and progesterone receptor . The survival rate of patients with nm23-H1 expression was significantly higher than that of patients without nm23-H1expression. The 5-year survival rate was 90.5% and 55.3% respectively （P<0.05）. Conclusion nm23-H1 gene may play a role in the inhibitory effect on t[1] [2] 下一页
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