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先天性心脏病合并肺动脉高压一氧化氮合酶mRNA表达及临床意义 |
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作者：封加涛，苏艳玲，龚光甫，胡冬煦，曹亚
【关键词】 心脏缺损,先天性；高血压,肺性；一氧化氮合酶；RNA,信使
【Abstract】 AIM: To explore the pathophysiological significance of nitric oxide(NO) and nitric oxide synthase(NOS) in congenital heart defects with pulmonary hypertension. METHODS: Twentyfour patients with congenital heart defects were divided into 3 groups: mild pulmonary hypertension group(n=8), moderate or severe pulmonary hypertension group(n=9), and nonpulmonary hypertension group(n=7). NOS mRNA expression was detected in lung tissues with reverse transcriptase polymerase chain reaction (RTPCR). RESULTS: The NOS mRNA expression levels in the patients with moderate or severe pulmonary hypertension were much lower than those in the ones with mildpulmonary hypertension or nonpulmonary hypertension (P<0.05). There was an inverse correlation between the NOS mRNA expression level and the pulmonary arteriopathy in the patients with pulmonary hypertension (r=-0.833, P<0.01). CONCLUSION: In patients with congenital heart defects associated with pulmonary hypertension, NO and NOS play a role in pathological process of pulmonary arteriopathy, and the NOS mRNA expression level was proportional to the severity of pulmonary hypertension or pulmonary arteriopathy.
【Keywords】 heart defects, congenital; hypertension, pulmonary; nitric oxide synthase; RNA, messenger
【摘要】 目的： 了解一氧化氮（NO）和一氧化氮合酶（NOS）在先天性心脏病合并肺动脉高压中的病理生理作用. 方法： 将24例左向右分流先天性心脏病患者分为三组：轻度肺动脉高压8例，中重度肺动脉高压9例和无肺动脉高压7例,应用逆转录多聚酶链式反应（RTPCR）检测患者肺组织中NOS mRNA的表达. 结果: NOS mRNA表达水平在中重度肺高压组较轻度肺高压组和无肺高压组显著减低（P<0.05）；NOS mRNA表达与肺高压肺血管病变程度呈负相关（r=-0.833, P<0.01）. 结论: NOS, NO 参与先[1] [2] [3] [4] [5] 下一页
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