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头颈部原发性非霍奇金恶性淋巴瘤50例临床分析 |
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【关键词】 头颈部肿瘤
【摘要】 目的 探讨头颈部原发性非霍奇金淋巴瘤（NHL）的临床特征及免疫学表型特点。方法 对经病理确诊的50例头颈部原发性非霍奇金淋巴瘤的临床资料和细胞免疫表型做回顾性总结分析。结果 本组病例发病高峰年龄为20~40岁，原发部位鼻腔最多，其次为鼻咽部、扁桃体及舌底。临床表现主要以原发器官的症状为主，缺乏特异性。体征多以结节状或菜花状肿块型最多，其次为肿块伴溃烂型，单纯的溃烂型较少。结论 细胞免疫学表型结果显示：来源于T细胞者占70%，来源于B细胞者占30%。鼻腔原发性NHL以T/NK细胞为主，占56%。鼻咽部、扁桃体原发性NHL以B细胞为主，占22%。
【关键词】 头颈部肿瘤；淋巴瘤，非霍奇金；免疫组织化学
【Abstract】 Objective We sought to investigate the clinical features as well as characteristics of the immunological forms with respect to the idiopathically head-neck non-Hodgkin’s lymphoma （henceforth NHL）.Methods Our study was based on the analysis and conclusions of 50 instances who had been confirmed pathologically to suffer from the idiopathic NHL in the head-neck area，examining retrospectively the clinical records and characteristics of the immunological forms associated with the NHL.Results We found that the incidence of this disease was particularly high amongst the age between 20~40，with the idiopathy most commonly found in the nosal cavity followed by the nasopharynx，tosil，and lastly underneath the lingua.The clinical characteristics were mostly limited to the originally infected organs，therefore lacking of specificity.The symptoms mainly took the forms of tuberculous or cauliflower tumors，then ulcerous tumors，with very few ulcerous.Conclusion Based on celluar immunology，our results suggest that those originating from T-cells account for 70%;whilst those originating from B-cells account for 30%.The idiopathic NHL associated with nasal cavity is mainly attributed to T/NK-cells accounting for 56%;whereas those associated with the nasopharynx and tosil might be mostly attributed to B-cells accounting for 22%.
【Key words】 head-neck tumors;lymphoma,non-Hodgkin;immunohistochemistry
恶性淋巴瘤是来自淋巴系统及网状内皮系统的非上皮性恶性肿瘤。非霍奇金淋巴瘤（NHL）常发生在淋巴结内，而首发于淋巴结外的恶性淋巴瘤仅占全身恶性淋巴瘤的10%~15%，易于广泛播散。头颈部恶性淋巴瘤多见于颈淋巴结、鼻腔、鼻咽部、扁桃体、咽后壁、上颌窦、舌等。其恶性程度高，临床表现复杂，预后较差，近年来生存率有所提高，常规的病理检查[1] [2] [3] [4] 下一页
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