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人类冻融胚胎移植技术的临床应用 |
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作者：王晓红，罗亚宁，李丽，杨艳红，闫凯麟，黄剑磊，闵保华
【关键词】 冻融
Clinical application of transferring cryopreserved human embryos
【Abstract】 AIM: To study the clinical application of transferring frozenthawed embryos and to analyze the factors influencing the outcome of frozenthawed embryos transfer (FET). METHODS: Eighty FET cycles in 63 cases from September 2003 to December 2004 were analyzed retrospectively. The suppernumberary embryos obtained from in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) were cryopreserved by slow freezing and rapid thawing method. RESULTS: Two hundred and sixtynine out of the 392 thawed embryos survived, with an embryo survival rate of 68.62%. The pregnancy rate was 23.75% per FET cycle. The pregnancy rate was significantly higher in the group of transferring 3 embryos than that of transferring ≤2 embryos（30.91% vs 8%, P<0.05）. There was significant difference between the conceived and nonconceived cycles in term of the rate of cleavage integrality and the percentage of quality embryos （67.28% vs 60.09%, 89.09% vs 73.55%, respectively P<0.025）. CONCLUSIONS: The number and quality of frozenthawed embryos transferred are the most important factors influencing the pregnancy rate after frozenthawed embryo transfer.
【Keywords】 frozenthawed; embryo cryopreservation; embryo transfer; pregnancy rate
【摘要】 目的： 研究冻融胚胎移植的临床应用及分析影响冻融胚胎移植妊娠率的相关因素. 方法： 对63例80个冻融胚胎移植周期进行回顾性分析，通过IVF或ICSI获得的剩余胚胎采用慢速法冷冻保存，快速法解冻复苏. 结果： 解冻392个胚胎，成活269个胚胎，胚胎复苏率为68.62%. 周期临床妊娠率为23.75%. 每周期植入3个胚胎组的临床妊娠率显著高于植入≤2个胚胎组（χ2=4.98, P<0.05）. 妊娠周期胚胎细胞完整率及优质胚胎率显著高于非妊娠周期（67.28% vs 60.09%, 89.09% vs 73.55%，均为P<0.025）. 结论： 冻融胚胎移植的成功率与移植胚胎的数量和质量密切相关.
【关键词】 冻融；冷冻胚胎；胚胎移植；妊娠率
0引言
胚胎冷冻技术是将胚胎放入冷冻保护剂中，在超低温环境中保存，需要时再将胚胎解冻复苏的技术，它是“试管婴儿”即体外受精―胚胎移植（in vitro fertilization and embryo transfer, IVFET）技术的一项重要衍生技术. 在本生殖医学中心200309/200412间共接受IVF或单精子卵母细胞质内显微注射（intracytoplasmic sperm injection, ICSI）技术助孕治疗[1] [2] [3] [4] 下一页
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